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KMID : 0368019840070040349
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Journal of Soonchunhyang University
1984 Volume.7 No. 4 p.349 ~ p.357
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Drug Therapy During Pregnancy
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Abstract
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Developmental defects in man may be the result of genetic, environmental, or unknown causes. Although approximately 25% are clearly genetic in origin, drug exposure accounts for probably only 2% -3% of birth defects. Approximately 65% of defects are of unknown etiology but may be from combinations of genetic and environmental factors.
Today numerous drugs are prescribed to treat a variety of disorders may affect the course of a woman´s pregnancy, the health of her fetus or neonate, or her reproductive function. Therefore, information about drug therapy is necessary to provide quality health care and be aware of implications from the use of currently prescribed drugs. The effect of a teratogen is dependent upon;
1. The dose reaching the developing embryo or fetus.
2. The duration of exposure.
3. The gestational age at the time of exposure.
4. The genotypes of the mother and fetus.
5. The effect of other agents to which the embryo or fetus is simultaneously exposed. Proof of the teratogenicity or safety of an individual drug is consequently difficult to establish. A single teratogen may have multiple effects, depending upon the dose, the time in gestation, as well as host and environmental factors. Pregnant women should be advised to consult with a physician before taking prescription or over-the-counter medications.
Finally the conclusion is that all drugs should be used with caution throughout pregnancy, given only for specific indication at the minimum effective dose, and for the shortest duration necessary.
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